Brief synthesisThe Camino Real de Tierra Adentro constitutes a part of the Spanish Intercontinental Royal Route from Mexico City to Santa Fe. Criterion (ii): The Camino Real de Tierra Adentro became one of the most important routes to bond the Spanish Crown with its northern domains in the Americas. Criterion (iv): An ensemble of sites along the southern part of the Camino Real de Tierra Adentro, including examples of buildings, architectural and technological ensembles, illustrate a significant stage in human history - the Spanish colonial exploitation of silver and the transformation of associated rural and urban landscapes. IntegrityThe component parts of the serial nomination illustrate the variety and diversity of functions and physical components that reflect the impact of the Camino Real de Tierra Adentro. Although there is no overall coordinated formal management framework for all components, the National Conference of Governors has committed to support the project of the Camino Real de Tierra Adentro through the formation of a coordinating work group.