Those who win the Powerball must match all five Powerball numbers (from 1-69) and the Powerball number (from 1-26) either manually or using Quick Pick. In the spirit of dreaming big, let’s explore the biggest Powerball winners of all time. Key Points About This Article:The Powerball lottery is among the most popular lotteries in the U.S. given its reach and the size of the prizes awarded to lucky winners. Other Notable Powerball WinnersThinkstockA number of anonymous winners took home the next three largest Powerball jackpots. Two other jackpots amounting to more than $1 billion were won in the past two years, with a $1.326 billion prize won by Cheng and Duanpen Saephan & Laiza Chao of Oregon and a $1.08 billion prize won by Yanira Alvarez of California.