Credit: Nature Mental Health (2025). DOI: 10.1038/s44220-025-00501-8Research led by The Hong Kong Polytechnic University finds that regional fat distribution exerts distinct effects on brain structure, connectivity and cognition, revealing patterns not explained by body mass index (BMI). This raises questions about whether fat distribution, rather than overall body size, may provide more precise insights into brain aging and cognitive health. Findings suggest that brain health assessments and interventions may need to consider fat distribution, not just overall obesity with BMI, when addressing risks of cognitive decline. More information: Die Zhang et al, Regional adiposity shapes brain and cognition in adults, Nature Mental Health (2025).