The 49ers sit alone atop the NFC West at 3-0 after three weeks, with two road wins and two wins over divisional opponents. Also, their only fully healthy quarterback at this point is Adrian Martinez after backup Mac Jones aggravated a knee injury in the home opener. Jacob Cowing: Went down on Day 1 of training camp with a hamstring injury, then aggravated it after returning in August. Defensive lineKevin Givens: Suffered a pectoral injury in the preseason and went on injured reserve with a designation to return. Defensive backfieldMalik Mustapha: Tore his ACL in the 2024 season finale at Arizona and currently on the Physically Unable to Perform list along with Aiyuk, but could return later in the season.