The HELIX (Harvard Extension Live Interactive eXperience) Portable Blended Classroom allows Harvard faculty to teach to both classroom-based and remote students simultaneously from any classroom while removing the sense of distance and isolation that is frequently associated with synchronous online learning and teaching by students and instructors. The Portable Blended Classroom has been successfully used in a wide variety of classrooms across the Harvard campus by the Harvard Extension School, Harvard Summer School, Harvard College, and other Harvard professional schools.