At a time when COVID-19 cases are increasing in a second wave in many parts of the world and people are fatigued with the public health and social measures, #AfricaMaskWeek is being launched to sustain and increase mask-wearing as a protective measure among populations in Africa. Led by the Pandemic Action Network, in partnership with the Africa Centres for Disease Control and Prevention (Africa CDC), the African Union Office of the Youth Envoy, the African Youth Front on Coronavirus, Resolve to Save Lives, and many other organizations, this week-long social media campaign will encourage mask-wearing across the African continent.