At its core, to live in harmony or accordance with nature is to have a bigger picture view of your life and of the cosmic life in general. When so-called “good” things happen, we are content but do not lose sight of how the world works. Returning to the quote from the Enchiridion what Epictetus is telling us is to (i) remember that the world had good and bad things to it so do not get disappointed by having false expectations, (ii) that things happen independent of your volition and you must thus recognise you are not the epicentre of the world, so, do not have false wants, and (iii) that no particular project is necessarily viable at all times, and your ambitions must thus be kept in check while you operate with adaptability.