The school targets both students and researchers in high-performance computing interested in exploring the potential interactions between numerical simulation applications and compiler optimizations. The school will focus on applications whose regularity, use of data structures such as arrays, and numerical intensity may make the automation or semi-automation of optimizations both feasible and useful, concentrating in particular on polyhedral analysis and optimizations for GPGPUs and multicores. Note that this spring school is the second event of a larger thematic quarter on high performance computing (http://hpc-milyon.universite-lyon.fr/) organized in Lyon and around, with several events, from April to July 2016.