What is the Largest Pizza Chain in Colorado? According to the report, the largest pizza chain in Colorado is Domino's. What States Share the Largest Pizza Chain with Colorado? In the other states that border Colorado, Wyoming, Nebraska, and Arizona, Pizza Hut is the largest pizza chain. Tragic Colorado Story Inspired Once-Thriving Restaurant Chain For many years, Baby Doe’s Matchless Mine, a restaurant chain inspired by a historic Colorado figure, was a staple in the Centennial State.