Ms Nakyobe joined State House service in 1991 where she served as an assistant secretary in various departments of the State House, including Energy and Natural Resources department from 1991-1992, Tourism and Wild Life from 1993-1994, Office of the Vice President from 1994-95 and the State House from1995-1998. From 1998 through 2001, she served as Minister of State for Luweero Triangle in the Office of the Prime Minister then served as State Minister for Defence as well as State Minister for Microfinance State Minister for Fisheries onward to Chief Government Whip. Prior, Ms Opendi served as the Minister of State for Primary Healthcare from August 15, 2012 until June 6, 2016 and was previously the State Minister for Lands.