Mayo Clinic and eight other health organizations have launched the Advancing Clinical Trials at the Point of Care Coalition (ACT@POC) to improve patient care by giving clinicians quality clinical research evidence in real time to better evaluate treatments and therapeutics. The ACT@POC coalition will bring together health systems, community-based care organizations, health research organizations, and a more diverse group of patients and providers to support the design of adaptable clinical trials and to develop digital health tools that make clinical trials simpler to conduct and more accessible to patients.