Much more must be done at the FDA to combat the opioid crisis, and it requires a confirmed commissioner with Dr. Califf’s experience. The pandemic and the opioid crisis are only the start of the urgent list of reasons to confirm Dr. Califf: implementing legislation to reduce harm from combustible tobacco — still the leading cause of preventable death — while addressing the challenge of youth vaping; assuring that breakthrough medical products for unmet needs are developed efficiently, with the required evidence on safety and effectiveness; and assuring the safety of 85 percent of our nation’s food supply.