The U.S. healthcare system is “Big, fat, and sick.” So said professor of medicine Jag Singh, speaking at a recent conference in Boston—where his efforts to champion innovations in digital healthcare took center stage. Singh, a former clinical director of cardiology at Mass General Hospital, underscored the urgent need for innovations in digital healthcare. This sentiment was echoed at the Mass Brigham General's Assembly Row campus during the public opening of Medically Engineered Solutions in Healthcare (MESH) Core 2024, a two-day intensive healthcare innovation bootcamp. Sponsored by Harvard Innovation Labs, MESH Core aims at empowering biomedical startup CEOs, practicing physicians, medical researchers, and investors to drive innovation in healthcare. Other speakers from Harvard included Kate Coffman, associate professor Harvard Business School; Jorge Cortell-Albert, senior advisor, Healthcare and Life Sciences Harvard Innovation Laboratories; and Jeff Karp, professor of anesthesia, Harvard Medical School, who each offered their perspectives on the digital health transition in medicine and business.