He said barns should be kept clean and dry with good ventilation to reduce the risk of Mycoplasma bovis infection. Unfortunately for the control of Mycoplasma bovis, there really isn’t a “great vaccine, whether it would be autogenous or commercial for cattle,” Chapman said. Prevention is the best way to control mycoplasma flare-ups, which means targeting the environment, Chapman said. Even for conventional farms, facility and environmental management are the first, key steps to reducing mycoplasma risk. Maintaining a clean, dry, draft-free environment also helps prevent other respiratory diseases beyond mycoplasma.