Learn about Johne’s disease prior to calving season Johne's disease can be found in grasses fertilized with contaminated manure8 April 2024 8 April 2024 3 minute read 3 minute read By: By: Oklahoma State University North AmericaCalving season has more than a few cattle producers cautiously looking for colostrum or colostrum replacers, given what they already know about Johne’s disease, said Oklahoma State University experts. Most animals are infected with the Johne’s disease early in life, but clinical symptoms typically do not appear for many months. “The two most common clinical signs seen in cattle with Johne’s disease are diarrhea and weight loss, even though animals will seem to have good appetites,” Whitworth said. Bottle jaw is caused by low serum protein levels, which is important to maintain vessel structure in the body.”The best way to keep Johne’s disease out of a cattle herd is prevention. If the disease is present in a herd, the focus should be on manure management, culling infected cattle and keeping facilities clean.