Researchers from the University of Nottingham developed mathematical models and conducted on-farm research to explore the impact of wastewater flows and management practices on antimicrobial resistance (AMR) in slurry. The research is the first to investigate the effects of farm layout, the farm practices associated across different areas of the farm, and the impact these may have on the emergence and spread of AMR across the farm. Temporal fluctuations in cephalosporin-resistant Escherichia coli were observed and attributed to farm activities, specifically the disposal of spent copper and zinc footbath into the slurry system. The results highlight farm-specific opportunities to reduce AMR pollution, beyond antibiotic use reduction, including careful disposal or recycling of waste antimicrobial metals. This the first successful investigation into the removal of copper and zinc from a commercially available cattle footbath powder mix solution.