The topic for this article will focus on potential opportunities of preventing fresh cow mastitis through proper dry cow nutrition. This research did not define a blood concentration threshold but showed as blood concentration increases by 100 ng/ml there was a 60% reduction in mastitis risk. Research with trace minerals in dry cow diets has been less definitive in showing marked changes in mastitis risk. We need to properly formulate the dry cow diet to prevent potential disease concerns post-calving, including mastitis. Many dry cow diets are stripped down of supplementation to prevent overfeeding, but the minerals and vitamins remain essential to supplement.