Good biosecurity reduces risk of avian influenza in poultry and dairy NDSU Extension has guidance for reducing the risk of HPAI transmission on a property. Highly pathogenic avian influenza (HPAI) is a disease carried by wild birds and affects domestic birds and mammals. Avian influenza is caused by the influenza Type A virus, commonly known as influenza A. Positive cases of HPAI in backyard poultry, commercial poultry and dairy herds are currently occurring across the U.S.One of the first clinical signs of HPAI in poultry is sudden, unexplained death. Poultry and poultry products are safe to eat, and proper handling and cooking is always advised.