To address this challenge, researchers consolidated what the latest science has to say on current BRD vaccination practices and protocols during the cow-calf production phase. Their new review article, published in Applied Animal Science, identifies potential management practices—in particular vaccine timing—that could improve calf health and performance across the industry. The comprehensive review examined vaccination strategies across three critical phases of cattle development: maternal vaccination during pregnancy, early calf vaccination from birth through branding (60–120 days of age), and vaccination timing around weaning (approximately 205 days). While additional research is needed to evaluate cow-calf management interventions on feeder cattle outcomes, this review demonstrates the potential to maximize BRD vaccine effectiveness through strategic timing during early production phases, ultimately improving cattle health and performance throughout the beef supply chain. The article appears in the August special issue of Applied Animal Science, which showcases previous management and health effects on beef cattle finishing performance.