They offer profound possibilities for growth and healing, but they also carry risks and complexities we must approach with care. Here is a non-exhaustive list of risks associated with psychedelics, drawn from scientific evidence, history, and anecdotal accounts. These outcomes highlight the need for preparation, a trusted container and thoughtful integration so insights can be digested rather than overwhelm the nervous system. A medical review, ideally with a clinician familiar with these substances, helps determine whether psychedelic work is appropriate for your body at this time. Legal risks can touch employment, licensure, finances and family matters.