For most wild rabbits, their immune system resolves the infection and the growths regress eventually. This viral infection is rarely diagnosed in domestic rabbits, but it is serious when it is because the papillomas are more likely to become malignant. For domestic rabbits, if left untreated, it can progress to malignant cancer. Although unsettling to see these rabbits with SPV, veterinary professionals can see this story as a reminder of a long-known virus with occasional clinical significance, according to the AVMA. "It’s also a good opportunity to remind people not to touch wild rabbits and to keep their pets protected," he concluded.1References