Arizona is one of 39 undefeated Football Bowl Subdivision teams as they enter their first 2025 bye week. Most odds have Arizona in the middle of the Big XII after week three. After the bye, Arizona plays at Iowa State on September 27 in an ESPN primetime game. Iowa State has the best odds among the teams remaining on the 2025 Arizona schedule to go undefeated at +1000 which is 11th nationally. Arizona at Iowa State should be the biggest game in the Big XII in week five and the only one with undefeated teams.