The brain's reward system is like an internal coach that encourages us to survive and thrive. The brain's reward system can signal through the vagus nerve and sympathetic nervous system to suppress the body's inflammatory response. Although the reward system is not the most vital in the body, its proper function may be a significant indicator of overall health. In this regard, the brain reward system may be considered as a target for medication in elderly and severely ill patients to improve their treatment. As long as this system functions properly, we are willing to fight for our lives.