I have no idea how I will feel.”Chronic illness also brings change (that is typically unwanted), loss of control, and concern about the future. All of these factors can lead to a sense of helplessness in the face of loss and uncertainty. Fear of the unknown is common when living with chronic illness. While it is natural to feel intolerant toward uncertainty, because intolerance is associated with distress, it is important to practice managing and tolerating uncertainty. Tips for Managing Illness Uncertainty