For comparison with the following data, remember that those 2 randomized trials used lithium carbonate. This implies that nonplaque lithium inhibits plaque formation, creating a positive feedback loop: as lithium is sequestered in plaque, nonplaque lithium concentrations decrease; these lower nonplaque lithium levels allow more plaque formation, which increases lithium sequestration; and so on. Lithium Orotate vs Lithium CarbonateWon’t the extra dietary lithium get sequestered in plaque just like the mouse’s own brain lithium? To address this potential problem, the researchers noted that lithium orotate is less electrically charged than lithium carbonate and speculated that this might help lithium stay in the nonplaque space. Lithium orotate worked far better than lithium carbonate in preventing plaque development.