Cities are at the frontline of the toughest economic, environmental and social challenges today —but they also hold the key to drive radical change. Rapid urbanisation has fuelled meteoric growth—the region’s share of global GDP is expected to reach 50 per cent by 2040 – but its cities are also on the frontline of escalating climate threats. Cities are engines of social mobility, but they also deepen inequality and leave the most vulnerable exposed to climate shocks. Smart policy, green infrastructure and inclusive leadership are demonstrating that climate action will ignite, not inhibit, economic opportunities. ‍Cities: Possibilities 2025 will bring together leading minds across the ecosystem to forge powerful alliances and share breakthrough strategies to accelerate the transition to a sustainable urban future.