In Coralie Fargeat's indie hit The Substance, one of 2024's best horror movies, Demi Moore plays an aging Hollywood superstar who takes a mysterious drug on the promise that it will return her to her youth. It was part of 2024's movie-gore renaissance, which also saw Damien Leone's triumphantly gnarly Terrifier 3 beat out Joker: Folie à Deux to the number one spot during its opening weekend; earlier in the year, acid-blood-spurting Alien sequel Alien: Romulus became the second-highest-grossing film in the franchise after 2012's Prometheus, while the brutal slasher In a Violent Nature was one of the biggest hits at 2024's Sundance Film Festival.