One in eight adults in the United States now say they’ve taken these medications, fueling demand for body contouring procedures that get rid of or firm up loose skin. Loose skin can lead to rashes, infections and distressFor many people, loose skin can be troubling. Collagen creams probably won’t help tighten skin since they don’t change your skin at the biological level, Ross said. Experts say the only option to get rid of loose skin after major weight loss is skin removal surgery, trimming away the overhanging skin and tightening what remains. “I wear my loose skin as a badge of pride — look what I was able to accomplish,” she said.