(3)Undenatured Collagen: Multimodal Cartilage Preserving AgentUndenatured type II collagen (UC-II) retains its triple helix structure and glycosylation, unlike denatured forms. (8)Undenatured Collagen Type II (UC-II) - Safety and Practical Use in Indian PracticeUndenatured collagen type II (UC-II) has consistently shown a favorable safety profile, with a low incidence of mild, non-serious adverse events such as nausea and headache. Gupta A, Maffulli N. Undenatured type II collagen for knee osteoarthritis. “Efficacy of undenatured collagen in knee osteoarthritis: review of the literature with limited meta-analysis.” American journal of translational research vol. Role of undenatured collagen type ii in management of osteoarthritis: A hospital based study.