USA: Older adults prescribed baclofen or tizanidine for musculoskeletal conditions face a higher risk of injury compared to those taking cyclobenzaprine, a recent retrospective cohort study published in the Journal of the American Geriatrics Society has shown. Researchers included adults aged 65 to 99 who were prescribed baclofen, tizanidine, or cyclobenzaprine between 2008 and 2018. Tizanidine was associated with a 34% higher risk of composite injury outcomes (aHR 1.34). The 2023 American Geriatrics Society (AGS) Beers Criteria already recommend avoiding most skeletal muscle relaxants in older adults due to safety concerns, but baclofen and tizanidine are currently excluded. The findings emphasize the importance of careful prescribing of muscle relaxants in older adults, emphasizing the need for awareness of injury risks when considering baclofen or tizanidine in this population.