Previous studies have demonstrated that the L/A ratio predicts mortality among critically ill individuals. This research hypothesized that, due to the pathophysiological underpinnings, the L/A ratio might also reflect a patient’s volume status, a factor that strongly influences treatment decisions in the ICU. The results showed that an admission L/A ratio of ≥0.06 to be a powerful independent predictor of 30-day mortality. Overall, the study illuminates that L/A is not only a reliable predictor of poor prognosis but also a potential indirect marker of fluid deficits in critically ill patients. Association of the Lactate/Albumin Ratio with Mortality and Hypovolemia in Critically Ill Patients: A Retrospective Cohort Study.