Once ingested or synthesized, creatine is converted to creatine phosphate and stored mostly in skeletal muscle (your muscle muscles like biceps, quadriceps, etc. The most-proven benefits of creatine supplementation, according to Candow, is that creatine “increases measures of muscle strength and muscle mass, preserves bone mass and strength,” but the compound can also have brain health benefits. A Sports Medicine article co-authored by Candow in June stated that creatine supplementation can boost the brain’s creatine content, which might explain some of the promising effects on brain function.