First, the patients who are recruited for the trials are those who have not reacted too negatively on getting such a drug before.52 They will likely therefore not react negatively to the new drug, which means that the trials will underestimate the harms of psychiatric drugs. Leading psychiatrists interpret the maintenance studies of neuroleptics and depression pills to mean that these drugs are highly effective at preventing new episodes of psychosis and depression, respectively,4 and that the patients should therefore continue taking the drugs for years or even for life.