Only two positive trials were published for this drug, while seven large, negative trials were not.127 Two positive trials are all it takes for FDA approval and the agency regards the others as failed trials, even though we see a failed drug. As with other psychiatric drugs, the long-term effects are harmful.4 This was demonstrated in the large US MTA trial that randomised 579 children and reported results after 3, 6, 8 and 16 years.142-146 After 16 years, those who consistently took their pills were 5 cm shorter than those who took very little, and there were many other harms.146 We can only speculate which permanent effects these drugs might have on the children’s developing brains.