All types of grout require regular cleaning, and cement-based grout requires occasional resealing, but the good news is if you keep on top of it, your grout will look better and last longer. How to clean grout “While highly alkaline cleaners may not harm tile or grout when used occasionally, they can strip away sealant from the grout over time, and you may need to eventually rejuvenate your sealant,” Marino explains.