The adjective comes from the noun fastidio (click here to hear it pronounced), meaning a bother, hassle, annoyance, discomfort, or inconvenience, which in turn comes from the Latin fastidium, meaning loathing or disgust. The noun fastidio is generally used in combination with the verb dare ('to give'), to talk about 'giving someone' trouble or annoyance by bothering them or putting them out; one of the most common uses is to ask someone whether they 'mind' something. As with the Italian verb annoiarsi (to get/be bored; literally: 'bore oneself'), you can infastidirsi ('get annoyed'; literally: annoy oneself), or something specific can be the source of your irritation: