However, the precise biological connection between obesity and Alzheimer’s disease has remained elusive. These sticky protein clumps are a hallmark of Alzheimer’s disease and play a central role in its development and progression. This could lower their risk of developing Alzheimer’s disease. Alzheimer’s disease already affects over 7 million Americans, and the number is expected to double by 2050. If successful, such biomarkers could lead to simple blood tests capable of identifying individuals at high risk for developing Alzheimer’s disease due to obesity-related metabolic changes.