and colleagues from the Postgraduate Institute of Medical Education and Research evaluated the decadal efficacy of structured family interventions. Therefore, the systematic review (2012–2024) screened 3,864 records to identify 15 high-quality Randomized Controlled Trials (RCTs) comparing therapist-guided family interventions to standard care for adolescents and adults with Substance Use Disorders (SUDs). The analysis prioritized substance reduction and family functioning as clinical endpoints, excluding purely digital or prevention-only models. The results suggest that family-centered interventions are broadly effective across various demographics, consistently reducing substance use levels and enhancing relational well-being in both adolescent and adult cohorts. Efficacy of Family-based Interventions in Addressing Substance Use Disorders: A Systematic Review on Randomized Controlled Trials.