One-Punch Man has one of the wildest rogues' galleries not just in manga and anime, but in the realm of comics, too. However, thanks to a threat-scaling system, monstrous entities in One-Punch Man can be better understood for their destructive potential. Thus, One-Punch Man's strongest villains, as listed below, have a dangerous influence over others, threatening the planet or even entire dimensions. Featured as the first story arc's antagonist in One-Punch Man, Dr. Genus was capable of creating even Dragon-level threats. Dr. Genus's goal in One-Punch Man was to achieve human perfection through evolution, thus the House of Evolution.