What’s the Difference Between Azelaic Acid and Niacinamide? Azelaic acid and niacinamide are two skin-brightening ingredients that target these dark spots, but they do so in different ways. And unlike niacinamide, azelaic acid is also available in prescription-strength formulas, though you’ll find lower concentrations in plenty of over-the-counter skincare products. “I typically recommend applying niacinamide first to support the skin barrier, followed by azelaic acid,” says Dr. Shah. ANUA Azelaic Acid 10 Hyaluron Redness Soothing Serum $22 at Ulta Beauty Sensitive skin may appreciate this lighter serum, which pairs 10 percent azelaic acid with hydrating ingredients including hyaluronic acid.