Experiments described in the study indicate that selected Brønsted-basic small molecules increase GTP hydrolysis by KRAS proteins carrying Q61 mutations. GTP hydrolysis involves substantial charge redistribution, particularly around the triphosphate group, and the transition state must be stabilized without prematurely displacing the nucleotide. Subject of Research: Small-molecule activation of GTP hydrolysis in KRAS-Q61 mutant proteinsArticle Title: Brønsted-basic small molecules activate GTP hydrolysis in KRAS-Q61 mutantsArticle References: Wang, YC., Chen, SC., Cao, Y. et al. Brønsted-basic small molecules activate GTP hydrolysis in KRAS-Q61 mutants. https://doi.org/10.1038/s41589-026-02291-1Image Credits: AI GeneratedDOI: https://doi.org/10.1038/s41589-026-02291-1Keywords: KRAS, KRAS-Q61, GTP hydrolysis, Brønsted bases, small molecules, cancer biology, RAS signaling, chemical catalysis, targeted therapy, oncology