These findings shed new light on the physiological roles of protein quality control at the ribosome. If this important quality control pathway does not work properly, defective and potentially toxic proteins accumulate. The RQC pathway marks these translation-arrested transmembrane proteins for elimination even before they leave the ribosome, thereby limiting their toxic effects,” Trentini added. The new findings reveal an intrinsic pitfall of an essential cellular process and shed light on a novel physiological role of protein quality control at the ribosome: dealing with difficult transmembrane proteins. WortgruppenZusammenhängende Worte werden als Wortgruppe gesucht, wenn Sie sie in Anführungsstriche setzen, z.