The effects can range from relatively mild dental problems in some people to severe bone disease and life-threatening complications in others. Because this was a retrospective study, the scientists analyzed information that had already been collected during patients’ medical care. The team examined symptoms including chronic pain, fractures, abnormal bone development and dental problems. More than 70% of patients experienced ongoing bone and muscle pain, and many needed several types of pain medicine to manage their symptoms. When it appears alongside unexplained fractures, early tooth loss, bone pain or other suggestive symptoms, HPP may be worth considering and further testing could help patients receive appropriate care sooner.