Is Botox resistance actually a thing? Dr Vishnu Nathan, aesthetics doctor at the Taktouk Clinic, agrees, describing true toxin resistance as “relatively uncommon in aesthetic medicine”. “In my experience, complete loss of response is uncommon,” says Dr Ahmed. “The first thing I would do is re-examine rather than automatically inject more,” says Dr Ahmed. For people who have been having particularly frequent treatments, Dr Ahmed says allowing a longer interval before treating again may also be worth considering.