Credit Michael Foth, TSMMy family loves grilled cheese. Credit Michael Foth, TSMHere's the question... butter or mayonnaise for your grilled cheese? I've always made grilled cheese sandwiches with butter, just like my mom and my grandma. A few years ago, I clicked some link about the "Amazing Way to Make the Best Grilled Cheese Sandwiches Ever!" I mentioned bacon grease earlier, and I do like that flavor a lot on grilled cheese.