According to the study, WFDC2 deficiency is associated with respiratory distress, and the researchers identified excessive or dysregulated ENaC activity as a contributing mechanism. Subject of Research: The role of WFDC2 deficiency and epithelial sodium channel activity in respiratory distress, and the potential of amiloride as a treatment. Article Title: Amiloride mitigates respiratory distress caused by WFDC2 deficiency via inhibiting the epithelial sodium channel. “Amiloride mitigates respiratory distress caused by WFDC2 deficiency via inhibiting the epithelial sodium channel.” https://doi.org/10.1038/s41467-026-76582-5Image Credits: AI GeneratedDOI: 10.1038/s41467-026-76582-5Keywords: WFDC2 deficiency, amiloride, epithelial sodium channel, ENaC, respiratory distress, airway epithelium, ion transport, drug repurposing, respiratory disease, precision medicine