MLB hasn't had a pitcher reach 300 strikeouts in a season since 2019, when New York Yankees ace Gerrit Cole racked up 326 punchouts during his final campaign with the Houston Astros. Could Milwaukee Brewers star Jacob Misiorowski end the drought this year? Even if his innings are cut back during the rest of the regular season though, he could potentially still reach 300 strikeouts. Misiorowski Reaching 300 Strikeouts 'Outrageous -- But Also Doable'Aug 9, 2026; Milwaukee, Wisconsin, USA; Milwaukee Brewers starting pitcher Jacob Misiorowski (32) delivers a pitch against the Minnesota Twins in the first inning at American Family Field. Bleacher Report's Zachary D. Rymer predicted Tuesday that the former second-round draft pick will indeed get to 300 strikeouts.