A single advanced compound can potentially be converted into several analogues by selectively replacing an azine C–H bond with a hydroxyl or amino group. Subject of Research: Direct azine C–H functionalization with water and ammonia using triarylphosphines to form C–O and C–N bonds. Article Title: Phosphine-mediated azine C–H couplings with water and ammoniaArticle References: Nottingham, K.G., Brunner, D.A., Dalmau, D. et al. “Phosphine-mediated azine C–H couplings with water and ammonia.” https://doi.org/10.1038/s41586-026-10991-wImage Credits: AI GeneratedDOI: 10.1038/s41586-026-10991-wKeywords: C–H functionalization, azines, pyridines, quinolines, diazines, triarylphosphines, water coupling, ammonia coupling, phosphorus(V), ligand coupling, late-stage functionalization, medicinal chemistry, agrochemical chemistry