A new review in Biomedical Technology examines bacterial extracellular vesicles, or BEVs, as emerging tools for precision oncology. It compares bacterial vesicles with mammalian extracellular vesicles and conventional nanocarriers, while highlighting advances in synthetic biology, microfluidic separation, surface modification and multiomics. Bacterial vesicles can retain harmful components, including inflammatory molecules derived from the bacterial membrane. For now, they remain an experimental technology, but their unusual ability to combine targeted transport with immune stimulation is pushing bacterial vesicles toward the center of precision cancer research. Keywords: bacterial extracellular vesicles, BEVs, cancer, precision oncology, drug delivery, cancer vaccines, immunotherapy, liquid biopsy, biomarkers, synthetic biology, nanomedicine, biotechnology