The U.S. National Science Foundation announced the NSF State and Regional Artificial Intelligence Infrastructure Hubs program, a $100 million initiative to drive AI-enabled scientific discovery and innovation across disciplines. “The State and Regional AI Infrastructure Hubs program supports a national mission to advance AI for science by expanding access to critical AI resources, strengthening state and regional ecosystems, and developing the workforce capabilities needed to harness these technologies. Specifically, NSF will invest in AI infrastructure professionals with the technical expertise to support researchers, students and educators in applying AI infrastructure for scientific discovery; connect meritorious research with AI Infrastructure hubs in their regions; and invest in faculty and educator training and instructional material development to build students’ skills, proficiency and knowledge in using computing, data and software systems for scientific research. AI Infrastructure Hubs are encouraged to integrate with national resources such as the NSF-led National AI Research Resource, providing the ability to surge and share resources beyond local capacity and enable dataset sharing. Many private-sector and philanthropic organizations, including NVIDIA, AMD, Intel, Dell Technologies, Hangar and the Secunda Innovation Fund, among others, intend to support participants in the State and Regional AI Infrastructure Hubs program.